Study highlights ‘anti-inflammatory’ effects of probiotic diet in healthy older adults


Researchers found that a significant number of healthy older adults had elevated levels of HsCRP (high-sensitivity C-reactive protein), a marker of inflammation, cardiovascular risk, heart attack and stroke . This supports the hypothesis that aging is associated with chronic low-grade inflammation.

However, enriching diets with Synbiotec products Synbio​ 1:1 mix of Lacticasibacillus rhamnosus​ IMC 501 and Lacticaseibacillus paracasei​IMC 502 caused significant reductions in HsCRP levels over six months, according to data published in the Journal of Applied Microbiology​.

The novelty of the new study was that it offered multiple different ways for seniors to consume the probiotic blend: the project offered six different food products, including yogurt, “mozzarella” cheese, fruit smoothies, ” ricotta”, from the “primo sale” cheese and chocolate. All have been formulated to provide 5 billion live cells per daily dose. Food supplements in the form of capsules were also provided to the participants. Participants were given the six different probiotic (or placebo) foods each week to consume one per day.

“ProbioSenior has proven to be an ideal support for healthy aging and can have a significant impact on the social health system”, ​wrote scientists from the University of Camerino and Synbiotec Srl.

“The 40% of the general population in Western countries are affected by functional disorders such as dyspepsia and irritable bowel syndrome (IBS), which includes constipation, bloating, digestive disorders, digestive pain and intermittent diarrhoea.

“Combining knowledge on the influence of diet on aging and its potential role in the prevention of age-related diseases, the way will open to make the microbiota the target of intervention to improve well-being. seniors.”

Study details

The researchers recruited 97 healthy Italian seniors to participate in their double-blind, placebo-controlled study. Participants were randomly assigned to either the probiotic group (n=59) or the placebo group (n=38) for six months.

The results showed that the Synbioconsuming participants had significantly increased levels of lactobacilli and bifidobacteria in their feces. Further analysis revealed that the probiotic group had lower levels of Proteobacteriaafter six months.

Additionally, the levels Akkermansiaceaeand Bifidobacteriawere higher in the probiotic group.

The researchers also found that levels of short-chain fatty acids (SCFAs) and butyric acid in particular were significantly higher after six months of probiotic supplementation.

“Overall, this study underscores the beneficial anti-inflammatory effect of prolonged feeding with functional foods fortified with ​Synbio through the modulation of the intestinal microbiota and the consequent increase in the production of SCFAs”, concluded the researchers.

Source: Journal of Applied Microbiology
Published online ahead of print, doi:​
“Impact of a probiotic diet on the well-being of a healthy senior: THE PROBIOSENIOR PROJECT”
Authors: C. Salvesi et al.


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