High consumption of sugary drinks linked to increased risk of IBD

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Disclosures: The authors report funding for the study from the National Natural Science Foundation and Hunan Province Research and Development Plan Key Project.


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Excess consumption of sugary drinks may increase the risk of inflammatory bowel disease, according to a study published in Food and Therapeutic Pharmacology.

“Ample evidence has linked its increasing incidence to dietary changes, including higher intake of fat, sugar, food additives and reduced intake of fibre. As one of the main sources of sugar-free beverages have been associated with inflammation-related health outcomes, but have received less attention in the area of ​​IBD,” Tianfu, from the gastroenterology department of Xiangya Third Hospital of Central South University in China, and colleagues wrote. “In vitro and in vivo research has linked beverages to IBD through gut microbiota dysbiosis and increased susceptibility to colitis, but population-based evidence was inconclusive.”



 Participants who consumed more than one unit of sugar-sweetened beverages per day had a higher risk of: A – Crohn's disease;  HR = 2.05 B – Ulcerative colitis;  HR = 1.31



Seeking to assess the association of sugary drinks, artificially sweetened drinks and natural juices with IBD risk, Fu and colleagues assessed 121,490 participants (mean age, 56.2 years; 96.9% Caucasian). without MII from the UK Biobank. The researchers measured food beverage consumption using a 24-hour food recall web questionnaire. Among eligible participants, 66.3% did not consume any sugary drinks and those who consumed more than one unit (defined as 250ml) per day likely had higher BMI, total energy intake and sugar intake.

During an average follow-up of 10.2 years, researchers reported 510 cases of incident IBD (41/100,000 person-years), including 143 cases of Crohn’s disease (12/100,000 person-years) and 367 cases of ulcerative colitis (30/100,000 person-years). 100,000 person-years).

Compared to participants who did not consume sugary drinks, participants who consumed more than one unit per day had a higher risk of IBD (HR=1.51; 95% CI, 1.11-2.05) , a more significant trend for CD (HR=2.05; 95% CI, 1.22-3.46) than CU (HR=1.31; 95% CI, 0.89-1.92). Conversely, artificially sweetened beverages (HR=0.85; 95% CI, 0.56-1.28) or natural juices (HR=1.08; 95% CI, 0.76-1 .53) were not associated with IBD risk.

“Our study suggested an association between excessive consumption of sugary drinks, rather than artificially sweetened drinks or natural juices, and IBD risk, while the trend was not significant,” Fu and colleagues concluded. “Our results, if proven causal, suggest a reduction in sugar-sweetened beverage consumption as a prevention strategy for IBD, particularly CD, but further studies are needed to confirm these findings and explore the underlying mechanism. underlying before public health policy can be conducted.”

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